GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus.

@article{Hammond2011GPR30CW,
  title={GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus.},
  author={Rebecca F. Hammond and Doug D Nelson and Robert B. Gibbs},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36 2},
  pages={182-92}
}
GPR30 is a novel, membrane-bound, G-protein coupled estrogen receptor (Filardo et al., 2002; Prossnitz et al., 2008). We hypothesize that GPR30 may mediate effects of estradiol (E2) on basal forebrain cholinergic neurons and cognitive performance. Recently we showed that G-1, a selective GPR30 agonist, enhances the rate of acquisition on a delayed matching… CONTINUE READING