GPR30/GPER1: searching for a role in estrogen physiology.

  title={GPR30/GPER1: searching for a role in estrogen physiology.},
  author={Bj{\"o}rn Olde and L. M. Fredrik Leeb-Lundberg},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={20 8},
Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the… CONTINUE READING