GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.

@article{Nazir2015GPR18IA,
  title={GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.},
  author={M. Nazir and H. Harms and Irene Loef and S. Kehraus and Fayrouz El Maddah and I. Arslan and V. Rempel and C. M{\"u}ller and G. K{\"o}nig},
  journal={Planta medica},
  year={2015},
  volume={81 12-13},
  pages={
          1141-5
        }
}
  • M. Nazir, H. Harms, +6 authors G. König
  • Published 2015
  • Biology, Medicine
  • Planta medica
  • The marine sponge-derived fungus Auxarthron reticulatum produces the cannabinoid receptor antagonist amauromine (1). Recultivation of the fungus to obtain further amounts for more detailed pharmacological evaluation of 1 additionally yielded the novel triterpene glycoside auxarthonoside (2), bearing, in nature, a rather rare sugar moiety, i.e., N-acetyl-6-methoxy-glucosamine. Amauromine (1), which inhibited cannabinoid CB1 receptors (Ki 0.178 µM) also showed antagonistic activity at the… CONTINUE READING
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