GPR171 expression enhances proliferation and metastasis of lung cancer cells

  title={GPR171 expression enhances proliferation and metastasis of lung cancer cells},
  author={S. H. Dho and Kwang-Pyo Lee and D. Jeong and Chang-Jin Kim and K. Chung and J. Kim and Bum-Chan Park and S. Park and Seon-Young Kim and K. Kwon},
  pages={7856 - 7865}
G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo. Immunostaining of clinical samples indicated that GPR171 was overexpressed in 46.8% of lung carcinoma tissues. Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor… Expand
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