GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids.

@article{Raptis2014GPR120OK,
  title={GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids.},
  author={Dimitri Aristotle Raptis and Perparim Limani and Jae Hwi Jang and Udo Ungethuem and Christoph Tschuor and Rolf E. Graf and Bostjan Humar and Pierre Alain Clavien},
  journal={Journal of hepatology},
  year={2014},
  volume={60 3},
  pages={
          625-32
        }
}
BACKGROUND & AIMS Many of the beneficial effects of ω3-fatty acids (ω3FAs) are being attributed to their anti-inflammatory properties. In animal models, ω3FAs also protect from hepatic ischemia reperfusion injury (IRI), a significant cause of complications following liver surgery. Omegaven®, a clinical ω3FA-formulation, might counteract the exaggerated inflammatory response underlying IRI, but the according mechanisms are unresearched. Recently, GPR120 has been identified as a first receptor… CONTINUE READING
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