GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

@article{Oh2010GPR120IA,
  title={GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects},
  author={Da Young Oh and Saswata Talukdar and Eun Ju Bae and Takeshi Imamura and Hidetaka Morinaga and Wuqiang Fan and Pingping Li and Wendell J. Lu and Steven M. Watkins and Jerrold M. Olefsky},
  journal={Cell},
  year={2010},
  volume={142},
  pages={687-698}
}
Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue… CONTINUE READING
Highly Influential
This paper has highly influenced 107 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 692 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…