GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis.

@article{Lan2009GPR119IR,
  title={GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis.},
  author={Hong Lan and Galya Vassileva and Aaron Corona and Li Liu and Hana Baker and Andrei Golovko and Susan J. Abbondanzo and Weiwen Hu and Shijun Yang and Yun Ning and Robert A. Del Vecchio and Frederique M. Poulet and Maureen Laverty and Eric L. Gustafson and Joseph A. Hedrick and Timothy J. Kowalski},
  journal={The Journal of endocrinology},
  year={2009},
  volume={201 2},
  pages={219-30}
}
G protein-coupled receptor 119 (GPR119) is expressed in pancreatic islets and intestine, and is involved in insulin and incretin hormone release. GPR119-knockout (Gpr119(-/-)) mice were reported to have normal islet morphology and normal size, body weight (BW), and fed/fasted glucose levels. However, the physiological function of GPR119 and its role in… CONTINUE READING