GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity.

Abstract

GPR105, a G protein-coupled receptor for UDP-glucose, is highly expressed in several human tissues and participates in the innate immune response. Because inflammation has been implicated as a key initial trigger for type 2 diabetes, we hypothesized that GPR105 (official gene name: P2RY14) might play a role in the initiation of inflammation and insulin… (More)
DOI: 10.4049/jimmunol.1103207

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@article{Xu2012GPR105AP, title={GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity.}, author={Jianfeng Xu and Hidetaka Morinaga and Dayoung Oh and Pingping Li and Ai Chen and Saswata Talukdar and Ya{\"e}l Mamane and Joseph A. Mancini and Andrea R. Nawrocki and Eduardo Rodolfo Lazarowski and Jerrold M. Olefsky and Jane Kim}, journal={Journal of immunology}, year={2012}, volume={189 4}, pages={1992-9} }