GPR10 deficiency in mice results in altered energy expenditure and obesity.

@article{Bjursell2007GPR10DI,
  title={GPR10 deficiency in mice results in altered energy expenditure and obesity.},
  author={Mikael Bjursell and Maria E Lenner{\aa}s and Melker G{\"o}ransson and Anders Elmgren and Mohammad Bohlooly-Y},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={363 3},
  pages={
          633-8
        }
}
In this study, mice carrying a disrupted gene encoding GPR10 (GPR10 KO) were studied to elucidate the function and importance of this receptor regarding metabolism. Female and male GPR10 KO mice had higher body weight after 11 and 15 weeks of age, respectively. The increased body weight was a result of increased fat mass. The obesity was much more pronounced in female mice, which also had a significant decrease in energy expenditure. In correlation to obesity, higher plasma levels of leptin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-4 of 4 citations