GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release.


Neuronal membrane glycoprotein gene (GPM6B) encodes a membrane glycoprotein that belongs to the proteolipid protein family. We identified GPM6B as a gene that is strongly upregulated during osteoblast differentiation. To investigate the role of GPM6B in the process of bone formation, we silenced GPM6B expression during osteogenic differentiation of human… (More)
DOI: 10.1002/jbmr.435