GPIIb/IIIa Inhibitor-Induced Dethrombosis

  title={GPIIb/IIIa Inhibitor-Induced Dethrombosis},
  author={Mark I. Furman and Andrew L Frelinger and Alan D Michelson},
  journal={Journal of Thrombosis and Thrombolysis},
GPIIb/IIIa inhibitors have demonstrated clinical benefit in patients with acute coronary syndromes and in those undergoing percutaneous coronary intervention. As opposed to the well documented prevention of platelet aggregation by GPIIb/IIIa inhibitors, we here discuss the less well appreciated reversal of platelet aggregation by, and dethrombotic effects of, GPIIb/IIIa inhibitors. In vivo evidence for GPIIb/IIIa inhibitor-induced dethrombosis includes animal models of arterial thrombosis and… CONTINUE READING
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