GPI 6150 prevents H(2)O(2) cytotoxicity by inhibiting poly(ADP-ribose) polymerase.

Abstract

GPI 6150 (1,11b-dihydro-[2H]benzopyrano[4,3,2-de]isoquinolin-3-one) is a novel inhibitor of poly(ADP-ribose) polymerase (PARP). It has demonstrated efficacy in rodent models of focal cerebral ischemia, traumatic brain injury, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine damage to dopaminergic neurons, regional myocardial ischemia, streptozotocin-induced… (More)

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@article{Zhang2000GPI6P, title={GPI 6150 prevents H(2)O(2) cytotoxicity by inhibiting poly(ADP-ribose) polymerase.}, author={Jianyi Zhang and Susan L Lautar and S Huang and Chris M. Ramsey and Annie K Y Cheung and J Li}, journal={Biochemical and biophysical research communications}, year={2000}, volume={278 3}, pages={590-8} }