GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts.

@article{Marco2014GPER1IR,
  title={GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts.},
  author={Paola De Marco and Enrica Romeo and Adele Vivacqua and Roberta Malaguarnera and Sergio Abonante and Francesco Romeo and Vincenzo Pezzi and Antonino Belfiore and Marcello Maggiolini},
  journal={Endocrine-related cancer},
  year={2014},
  volume={21 5},
  pages={739-53}
}
Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, including estrogen signaling. As G protein estrogen receptor 1… CONTINUE READING