GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts

Abstract

Cancer-associated fibroblasts (CAFs) are crucial co-mediators of breast cancer progression. Estrogen is the predominant driving force in the cyclic regulation of the mammary extracellular matrix, thus potentially affecting the tumor-associated stroma. Recently, a third estrogen receptor, estrogen (G-protein-coupled) receptor (GPER), has been reported to be… (More)
DOI: 10.1530/ERC-13-0237

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