GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment.

Abstract

Increasing evidence suggest that excessive inflammatory responses from overactivated microglia play a critical role in Parkinson's disease (PD), contributing to, or exacerbating, nigral dopaminergic (DA) degeneration. Recent results from our group and others demonstrated that selective activation of G protein-coupled estrogen receptor (GPER) with the… (More)
DOI: 10.1016/j.bbi.2017.04.016

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