GPER-1 and estrogen receptor-β ligands modulate aldosterone synthesis.

@article{Caroccia2014GPER1AE,
  title={GPER-1 and estrogen receptor-β ligands modulate aldosterone synthesis.},
  author={Brasilina Caroccia and Teresa Maria Seccia and Abril Gonz{\'a}lez Campos and Francesca Gioco and Maniselvan Kuppusamy and Giulio Ceolotto and Eugenia Guerzoni and Francesca Simonato and Sara Mareso and Livia Lenzini and Ambrogio Fassina and Gian Paolo Rossi},
  journal={Endocrinology},
  year={2014},
  volume={155 11},
  pages={
          4296-304
        }
}
Fertile women have lower blood pressure and cardiovascular risk than age-matched men, which suggests that estrogens exert cardiovascular protective effects. However, whether 17 β-estradiol (E2) blunts aldosterone secretion, and thereby affects the gender dimorphism of blood pressure, is unknown. We therefore sought for the estrogen receptor (ER) subtypes in human adrenocortical tissues ex vivo by performing gene and protein expression studies. We also investigated the effect of E2 on… CONTINUE READING
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