GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.

@article{Menon2010GPCRK2,
  title={GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.},
  author={Prashanthi Menon and Guoyong Yin and Elaine M. Smolock and Michael J Zuscik and Chen Yan and Bradford C. Berk},
  journal={Journal of cellular physiology},
  year={2010},
  volume={225 3},
  pages={777-85}
}
G-protein-coupled receptor (GPCR) kinase 2 interacting protein-1 (GIT1) is a scaffold protein expressed in various cell types including neurons, endothelial, and vascular smooth muscle cells. The GIT1 knockout (KO) mouse has a pulmonary phenotype due to impaired endothelial function. Because GIT1 is tyrosine phosphorylated by Src kinase, we anticipated that GIT1 KO should have a bone phenotype similar to Src KO. Microcomputed tomography of the long bones revealed that GIT1 KO mice have a 2.3… CONTINUE READING