GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

@article{Hart2005GPCRinducedMO,
  title={GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.},
  author={Stefan Willi Hart and Oliver Martin Fischer and Norbert Prenzel and Esther Zwick-Wallasch and Matthias Schneider and Lothar Hennighausen and Axel Ullrich},
  journal={Biological chemistry},
  year={2005},
  volume={386 9},
  pages={845-55}
}
The epidermal growth factor receptor (EGFR) plays a key role in the regulation of important cellular processes under normal and pathophysiological conditions such as cancer. In human mammary carcinomas the EGFR is involved in regulating cell growth, survival, migration and metastasis and its activation correlates with the lack of response in hormone therapy. Here, we demonstrate in oestrogen receptor-positive and -negative human breast cancer cells and primary mammary epithelial cells a cross… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

ADAMs: key components in EGFR signalling and development

Nature Reviews Molecular Cell Biology • 2005
View 3 Excerpts

Similar Papers

Loading similar papers…