GPCR dimers fall apart.

@article{Lambert2010GPCRDF,
  title={GPCR dimers fall apart.},
  author={Nevin A. Lambert},
  journal={Science signaling},
  year={2010},
  volume={3 115},
  pages={pe12}
}
G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), transduce various sensory and nonsensory signals. It is now widely accepted that these receptors associate with each other as homomeric or heteromeric dimers or as higher-order oligomers. This realization raises a number of questions regarding the quaternary structure of GPCRs and the function of GPCR oligomers: How does ligand binding in one protomer affect an associated protomer? What is the functional… CONTINUE READING

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