GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.

@article{Nagareddy2010GPCRAT,
  title={GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.},
  author={Prabhakara Reddy Nagareddy and Kathleen M Macleod and John Hugh McNeill},
  journal={Cardiovascular research},
  year={2010},
  volume={87 1},
  pages={177-86}
}
AIMS The presence of metabolic abnormalities such as insulin resistance and elevated levels of various vasoconstrictor G-protein-coupled receptor (GPCR) agonists contributes to the development of hypertension. Recent studies have suggested a link between disease progression and activation of growth factor receptor signalling pathways such as the epidermal growth factor receptor (EGFR) by matrix metalloproteinases (MMPs). We hypothesized that excessive stimulation of GPCRs such as alpha(1… CONTINUE READING

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