GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function

@article{Opstelten2021GPA33IE,
  title={GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function},
  author={R. Opstelten and Jessica S. Suwandi and M. Slot and F. Morgana and A. Scott and S. Laban and T. Nikoli{\'c} and A. Turksma and Anna Kroeze and C. Voermans and J. Zwaginga and B. Roep and D. Amsen},
  journal={European Journal of Immunology},
  year={2021},
  volume={51}
}
The Ig superfamily protein glycoprotein A33 (GPA33) has been implicated in immune dysregulation, but little is known about its expression in the immune compartment. Here, we comprehensively determined GPA33 expression patterns on human blood leukocyte subsets, using mass and flow cytometry. We found that GPA33 was expressed on fractions of B, dendritic, natural killer and innate lymphoid cells. Most prominent expression was found in the CD4+ T cell compartment. Naïve and CXCR5+ regulatory T… Expand

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