GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans.

@article{Hahm2011GPA9IA,
  title={GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans.},
  author={Jeong-Hoon Hahm and Sunhee Kim and Young-Ki Paik},
  journal={Aging cell},
  year={2011},
  volume={10 2},
  pages={208-19}
}
Innate immune responses to pathogens are governed by the nervous system. Here, we investigated the molecular mechanism underlying innate immunity in Caenorhabditis elegans against Escherichia coli OP50, a standard laboratory C. elegans food. Longevity was compared in worms fed live or UV-killed OP50 at low or high density food condition (HDF). Expression of the antimicrobial gene lys-8 was approximately 5-fold higher in worms fed live OP50, suggesting activation of innate immunity upon… CONTINUE READING
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