GP43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus.

@article{Popi2002GP43FP,
  title={GP43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus.},
  author={Ana Flavia Flavia Popi and Jos{\'e} Daniel Lopes and Mario Mariano},
  journal={Cellular immunology},
  year={2002},
  volume={218 1-2},
  pages={
          87-94
        }
}
Macrophages constitute one of the primary cellular mechanisms that impairs parasite invasion of host tissues. The phagocytic and microbicidal properties of these cells can be modulated by specific membrane receptors involved in cell-microorganism interactions. Gp43, the main antigen secreted by Paracoccidiodes brasiliensis (Pb), the causative agent of Paracoccidioidomycosis, is a high mannose glycoprotein. The role played by gp43 in the pathogenesis of the disease is not completely known. Here… CONTINUE READING

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