GP130 cytokines and bone remodelling in health and disease.

  title={GP130 cytokines and bone remodelling in health and disease.},
  author={Natalie A Sims and Nicole C. Walsh},
  journal={BMB reports},
  volume={43 8},
Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF). Apart from contributing to inflammation, gp130 signalling cytokines also function in the maintenance of bone homeostasis. Expression of each of these cytokines and their ligand-specific receptors is observed in bone and joint cells, and bone-active hormones and inflammatory… CONTINUE READING


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