GP120: target for neutralizing HIV-1 antibodies.

  title={GP120: target for neutralizing HIV-1 antibodies.},
  author={Ralph Pantophlet and Dennis R. Burton},
  journal={Annual review of immunology},
The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate the surface of HIV-1 and a major target for neutralizing antibodies. However, immunization with recombinant gp120 does not elicit neutralizing antibodies against multiple HIV-1 isolates (broadly neutralizing antibodies), and gp120 failed to demonstrate vaccine efficacy in recent clinical trials. Ongoing crystallographic studies of gp120 molecules from HIV-1 and SIV increasingly reveal how conserved… CONTINUE READING