GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans

@article{Yin2017GOP1PA,
  title={GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans},
  author={Jianhua Yin and Yaling Huang and Pengfei Guo and Siqi Hu and Sawako Yoshina and Nan Xuan and Qiwen Gan and S. Mitani and Chonglin Yang and Xiaochen Wang},
  journal={The Journal of Cell Biology},
  year={2017},
  volume={216},
  pages={1775 - 1794}
}
Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within plasma membrane–derived phagosomes. Maturation of phagosomes involves a series of membrane-remodeling events that are governed by the sequential actions of Rab GTPases and lead to formation of phagolysosomes, where cell corpses are degraded. Here we identified gop-1 as a novel regulator of apoptotic cell clearance in Caenorhabditis elegans. Loss of gop-1 affects phagosome maturation through the RAB… Expand
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