GNQ-209P Mutation in Metastatic Uveal Melanoma and Treatment Outcome

  title={GNQ-209P Mutation in Metastatic Uveal Melanoma and Treatment Outcome},
  author={N. Abdel Karim and Ihab Eldessouki and Ahmad Taftaf and Deeb Ayham and O. Gaber and Abouelmagd Makramalla and Z. Corr{\^e}a},
  journal={Case Reports in Oncological Medicine},
  • N. Abdel Karim, Ihab Eldessouki, +4 authors Z. Corrêa
  • Published 2018
  • Medicine
  • Case Reports in Oncological Medicine
  • Metastatic prognosis in uveal melanoma is assessed by gene expression profiling (GEP) testing of the tumor cells, usually obtained by fine needle aspiration (FNA). GEP has demonstrated high accuracy in distinguishing class I and II tumors, both having different metastatic potential. Transcriptomic studies identified distinct mutations including somatic mutations in GNAQ and GNA11, detected in more than 80%, and contribute to the upregulation of the mitogen-activated protein kinase (MAPK… CONTINUE READING
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