Corpus ID: 55219507

GNQ-209 P Mutation in Metastatic Uveal Melanoma and Treatment Outcome

  title={GNQ-209 P Mutation in Metastatic Uveal Melanoma and Treatment Outcome},
  author={N. Karim and Ihab Eldessouki and Ahmad Taftaf and Deeb Ayham and O. Gaber and Abouelmagd Makramalla and Z. M. Corr{\^e}a},
  • N. Karim, Ihab Eldessouki, +4 authors Z. M. Corrêa
  • Published 2018
  • Metastatic prognosis in uveal melanoma is assessed by gene expression profiling (GEP) testing of the tumor cells, usually obtained by fine needle aspiration (FNA). GEP has demonstrated high accuracy in distinguishing class I and II tumors, both having different metastatic potential. Transcriptomic studies identified distinct mutations including somatic mutations in GNAQ and GNA11, detected in more than 80%, and contribute to the upregulation of the mitogen-activated protein kinase (MAPK… CONTINUE READING
    1 Citations

    Figures and Tables from this paper


    Oncogenic mutations in GNAQ occur early in uveal melanoma.
    • 276
    • PDF
    Biology of advanced uveal melanoma and next steps for clinical therapeutics
    • 69
    Mutational Profile of GNAQ Q209 in Human Tumors
    • 50
    • PDF
    Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma
    • 130
    • PDF
    A Case Study in Advanced Lung Cancer Patients with Vimentin Over Expression.
    • 11
    Nab-paclitaxel in patients with metastatic melanoma
    • 8