GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.

@article{Frey2005GNAS1TP,
  title={GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.},
  author={Ulrich Hermann Frey and Hakan Alakus and Jeremias Wohlschlaeger and Klaus Juergen Schmitz and G{\"u}nther Winde and Hans G van Calker and Karl-Heinz J{\"o}ckel and Winfried Siffert and Kurt Werner Schmid},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 14},
  pages={5071-7}
}
PURPOSE Signaling via the G protein Galpha s pathway is linked to proapoptotic processes in cancer cell lines. We have recently shown an association between the GNAS1 T393C polymorphism and disease progression in patients with bladder cancer with homozygous TT genotypes displaying increased transcription of Galpha s and a more favorable clinical course compared with C-allele carriers. EXPERIMENTAL DESIGN In the present study, 151 patients with sporadic colorectal cancer were retrospectively… CONTINUE READING