GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.

@article{Matthaei2012GNASC2,
  title={GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.},
  author={Hanno Matthaei and Jian Wu and Marco dal Molin and Marija Debeljak and Philipp Lingohr and Nora Katabi and David S. Klimstra and N. Volkan Adsay and James R. Eshleman and Richard David Schulick and Kenneth W. Kinzler and Bert Vogelstein and Ralph H. Hruban and Anirban Maitra},
  journal={HPB : the official journal of the International Hepato Pancreato Biliary Association},
  year={2012},
  volume={14 10},
  pages={677-83}
}
BACKGROUND Activating point mutations of GNAS at codon 201 have been detected in approximately two thirds of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Intraductal papillary neoplasms of the bile ducts (IPNBs) morphologically resemble pancreatic IPMNs. This study sought to assess the mutational status of GNAS at codon 201 in IPNBs. METHODS Thirty-four patients were included. DNA from microdissected IPNBs was subjected to a polymerase chain reaction and ligation method… CONTINUE READING

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