GNAS Mutations Identify a Set of Right-Sided, RAS Mutant, Villous Colon Cancers

@inproceedings{Fecteau2014GNASMI,
  title={GNAS Mutations Identify a Set of Right-Sided, RAS Mutant, Villous Colon Cancers},
  author={Ryan E. Fecteau and James D. Lutterbaugh and Sanford D Markowitz and Joseph Willis and Kishore Guda},
  booktitle={PloS one},
  year={2014}
}
The purpose of this study is to determine the genetic frequency of GNAS activating mutations in colorectal cancer and the corresponding pathology of GNAS mutant tumors. Oncogenic mutations in GNAS have been described in a number of neoplasms including those of the pituitary, kidney, pancreas, and, more recently, in colon cancer. To ascertain the frequency in colon cancer we employed a sensitive pyrosequencing platform for mutation detection of the R201C and R201H GNAS hotspots in tumor samples… CONTINUE READING