GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis.

@article{Lu2010GMPgradePW,
  title={GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis.},
  author={Ying-jie Lu and Luciana de Campos Leite and Viviane M. Gonçalves and Waldely de Oliveira Dias and Celia Liberman and Fernando Fratelli and Mark R. Alderson and Andrea Tate and J. P. Maisonneuve and George Robertson and R. Graca and Sabina Sayeed and Claudette M. Thompson and Porter W. Anderson and Richard Malley},
  journal={Vaccine},
  year={2010},
  volume={28 47},
  pages={7468-75}
}
Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement, here we evaluated subcutaneous injection. Strain RM200 was engineered to be capsule-negative, autolysin-negative, and to express a non-toxic mutant pneumolysoid. Liter-scale and 60-l Good… CONTINUE READING

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