GMCSF-armed vaccinia virus induces an antitumor immune response.

@article{Parviainen2015GMCSFarmedVV,
  title={GMCSF-armed vaccinia virus induces an antitumor immune response.},
  author={Suvi T. Parviainen and Marko T. Ahonen and Iulia Diaconu and Anja Kipar and Mikko Siurala and Markus V{\"a}h{\"a}-Koskela and Anna Kanerva and Vincenzo Cerullo and Akseli Hemminki},
  journal={International journal of cancer},
  year={2015},
  volume={136 5},
  pages={1065-72}
}
Oncolytic Western Reserve strain vaccinia virus selective for epidermal growth factor receptor pathway mutations and tumor-associated hypermetabolism was armed with human granulocyte-macrophage colony-stimulating factor (GMCSF) and a tdTomato fluorophore. As the assessment of immunological responses to human transgenes is challenging in the most commonly used animal models, we used immunocompetent Syrian golden hamsters, known to be sensitive to human GMCSF and semipermissive to vaccinia virus… CONTINUE READING
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