GMAP: a genomic mapping and alignment program for mRNA and EST sequence

  title={GMAP: a genomic mapping and alignment program for mRNA and EST sequence},
  author={Thomas D. Wu and Colin K. Watanabe},
  volume={21 9},
MOTIVATION We introduce GMAP, a standalone program for mapping and aligning cDNA sequences to a genome. The program maps and aligns a single sequence with minimal startup time and memory requirements, and provides fast batch processing of large sequence sets. The program generates accurate gene structures, even in the presence of substantial polymorphisms and sequence errors, without using probabilistic splice site models. Methodology underlying the program includes a minimal sampling strategy… CONTINUE READING
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