GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction.

@article{Biswas2006GM2EI,
  title={GM2 expression in renal cell carcinoma: potential role in tumor-induced T-cell dysfunction.},
  author={Kaushik Biswas and Amy L. Richmond and Patricia A. Rayman and Soumika Biswas and Mark Thornton and Gaurisankar Sa and Tanya Das and Renliang Zhang and Ali Chahlavi and Charles S. Tannenbaum and Andrew C. Novick and Ronald M. Bukowski and James H. Finke},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={
          6816-25
        }
}
Multiple mechanisms have been proposed to account for immune escape by tumors. Although gangliosides have long been known to suppress T-cell immunity, few studies have examined the effect of human tumor-derived gangliosides on immune responses. Here, we show that gangliosides isolated from renal cell carcinoma (RCC) cell lines and clear cell tumor tissue can induce apoptosis in peripheral blood T cells. The RCC tissue-derived gangliosides also suppressed IFN-gamma and, in many cases… CONTINUE READING

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