GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.

@article{Helling1995GM2KLHCV,
  title={GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.},
  author={Fiedhelm Helling and Shu-ping Zhang and Aijia Shang and Sucharita Adluri and Michele Jones Calves and R. Rao Koganty and Bryan Michael Longenecker and Tzy Jyun Yao and Herbert Friedrich Oettgen and Philip O. Livingston},
  journal={Cancer research},
  year={1995},
  volume={55 13},
  pages={
          2783-8
        }
}
The cell surface gangliosides GM2, GD2, and GD3 are often overexpressed in malignant melanoma. We have shown previously that immunization of melanoma patients with GM2 and Bacillus Calmette-Guérin induced an IgM antibody response in most patients and that patients with high titer GM2 antibodies showed increased survival. As is commonly seen with carbohydrate antigens (which are T independent), the IgM response was short lived, and an IgG response was rarely observed. To increase immunogenicity… CONTINUE READING

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