GM1 gangliosidosis (type 1) in a cat.

  title={GM1 gangliosidosis (type 1) in a cat.},
  author={Charmain G Barker and William F Blakemore and Anne Dell and Adam C Palmer and Phillip R Tiller and Bryan G. Winchester},
  journal={The Biochemical journal},
  volume={235 1},
A kitten with clinical and morphological symptoms of a neurovisceral lysosomal-storage disease has been shown to have a marked deficiency of acidic beta-D-galactosidase in the brain, kidney and spleen. Chromatography on concanavalin A-Sepharose and inhibition studies with 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine, a selective inhibitor of the neutral broad-specificity beta-D-galactosidase, have shown that the residual beta-D-galactosidase at pH 4.0 in the tissues of the affected cat is due… CONTINUE READING

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