GM1 ganglioside regulates the proteolysis of amyloid precursor protein

@article{Zha2004GM1GR,
  title={GM1 ganglioside regulates the proteolysis of amyloid precursor protein},
  author={Qinqin Zha and Yanyan Ruan and Tobias Hartmann and Konrad Beyreuther and Dai Jing Zhang},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={946-952}
}
Plaques containing amyloid β-peptides (Aβ) are a major feature in Alzheimer's disease (AD), and GM1 ganglioside is an important component of cellular plasma membranes and especially enriched in lipid raft. GM1-bound Aβ (GM1/Aβ), found in brains exhibiting early pathological changes of AD including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed. However, the role of GM1 in amyloid β-protein precursor (APP) processing… CONTINUE READING

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