GM1 ganglioside regulates the proteolysis of amyloid precursor protein

  title={GM1 ganglioside regulates the proteolysis of amyloid precursor protein},
  author={Qinqin Zha and Yanyan Ruan and Tobias Hartmann and Konrad Beyreuther and Dai Jing Zhang},
  journal={Molecular Psychiatry},
Plaques containing amyloid β-peptides (Aβ) are a major feature in Alzheimer's disease (AD), and GM1 ganglioside is an important component of cellular plasma membranes and especially enriched in lipid raft. GM1-bound Aβ (GM1/Aβ), found in brains exhibiting early pathological changes of AD including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed. However, the role of GM1 in amyloid β-protein precursor (APP) processing… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 36 extracted citations

Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis • 2003
View 11 Excerpts
Highly Influenced

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2014


Publications referenced by this paper.
Showing 1-10 of 40 references

Lipid analyses of human brain rafts

K Molander-Melin M. Blennow, N Bogdanovic, JE Mansson, P. Fredman
J Neurochem • 2003

Similar Papers

Loading similar papers…