GM1 ganglioside induced myocardial restoration and survival of mice with experimental Chagas' disease.

@article{Isasi1999GM1GI,
  title={GM1 ganglioside induced myocardial restoration and survival of mice with experimental Chagas' disease.},
  author={S Cossy Isasi and Alicia Ruth Fern{\'a}ndez and Patricia Adriana Paglini and Delia I. H. Bronia},
  journal={Acta tropica},
  year={1999},
  volume={73 3},
  pages={295-302}
}
In a previous work, our group reported that Albino Swiss male mice inoculated with T. cruzi to develop acute lethal infection by day 15 decreased parasitemia and survived when treated with total brain gangliosides (GT; 1 mg, daily). In this paper, GT were replaced by GM1 in 0.1 mg dose that caused diminished parasitemia from day 15 to 30 and survival of 80% by day 120 p.i. Treatment with GT 0.15 mg was ineffective. This indicates that GT effect was due to GM1 and that more sialyl residues on… CONTINUE READING