GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats

@article{Andreassen1994GM1GA,
  title={GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats},
  author={Ole A. Andreassen and Hugo Arild J\orgensen},
  journal={Psychopharmacology},
  year={1994},
  volume={116},
  pages={517-522}
}
Tardive dyskinesia (TD) is a serious side-effect of long-term treatment with neuroleptics. To investigate if TD may be a result of neuroleptic-induced excessive stimulation of striatal glutamate receptors, the effect of the anti-excitotoxic GM1 ganglioside was studied in a rat model of TD. In an acute experiment each of four groups of rats was treated with GM1 20 mg/kg SC + saline IP, saline SC + haloperidol 1.2 mg/kg IP, GM1 SC + haloperidol IP, or saline SC + saline IP. In a subsequent long… CONTINUE READING
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Relationship between motor effects in rats following acute and chronic haloperidol treatment

  • HA Jorgensen, OA Andreassen, K Hole
  • Psychopharmacology
  • 1994
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