GM1 ganglioside administration partially counteracts the morphological changes associated with haloperidol treatment within the dorsal striatum of the rat

@article{Meshul1995GM1GA,
  title={GM1 ganglioside administration partially counteracts the morphological changes associated with haloperidol treatment within the dorsal striatum of the rat},
  author={Charles K. Meshul and Regina K. Stallbaumer and Christine M Allen},
  journal={Psychopharmacology},
  year={1995},
  volume={121},
  pages={461-469}
}
Haloperidol, a typical antipsychotic drug, causes an increase in the mean percentage of synapses within the striatum containing a discontinuous, or perforated, postsynaptic density (PSD) following 1 month of treatment (Meshul et al. 1994). This effect is not observed with the atypical antipsychotic drug, clozapine, following subchronic administration… CONTINUE READING