GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease

Abstract

The earliest event so far known that occurs in the brain affected with Alzheimer's disease (AD) is the deposition and fibril formation of amyloid β–protein (Aβ). Aβ is cleaved from a glycosylated membrane protein, called β–amyloid protein precursor, and normally secreted into the extracellular space. Here we report on the presence of membrane–bound Aβ that… (More)
DOI: 10.1038/nm1095-1062

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