GM1 Softens POPC Membranes and Induces the Formation of Micron-Sized Domains.

  title={GM1 Softens POPC Membranes and Induces the Formation of Micron-Sized Domains.},
  author={Nico Fricke and Rumiana Dimova},
  journal={Biophysical journal},
  volume={111 9},
The influence of the glycolipid GM1 on the physical properties of POPC membranes was studied systematically by using different methods applied to giant and large unilamellar vesicles. The charge per GM1 molecule in the membrane was estimated from electrophoretic mobility measurements. Optical microscopy and differential scanning calorimetry were employed to construct a partial phase diagram of the GM1/POPC system. At room temperature, phase separation in the membrane was detected for GM1… CONTINUE READING
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