GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

@inproceedings{Zhu2009GMCSFRI,
  title={GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions},
  author={S Zhu and Mian Zhi Chen and Jenny Jongstra-Bilen and Myron I Cybulsky},
  booktitle={The Journal of experimental medicine},
  year={2009}
}
The contribution of intimal cell proliferation to the formation of early atherosclerotic lesions is poorly understood. We combined 5-bromo-2'-deoxyuridine pulse labeling with sensitive en face immunoconfocal microscopy analysis, and quantified intimal cell proliferation and Ly-6C(high) monocyte recruitment in low density lipoprotein receptor-null mice. Cell proliferation begins in nascent lesions preferentially at their periphery, and proliferating cells accumulate in lesions over time… CONTINUE READING

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