GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury.

Abstract

Exposure of mice to hyperoxia induces alveolar epithelial cell (AEC) injury, acute lung injury and death. Overexpression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the lung protects against these effects, although the mechanisms are not yet clear. Hyperoxia induces cellular injury via effects on mitochondrial integrity, associated with… (More)
DOI: 10.1152/ajplung.00276.2011

Topics

9 Figures and Tables

Cite this paper

@article{Sturrock2012GMCSFPA, title={GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury.}, author={Anne B Sturrock and Elfateh Seedahmed and Mustafa Mir-Kasimov and Jonathan P Boltax and Michael L. McManus and Robert T. Paine}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2012}, volume={302 3}, pages={L343-51} }