GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α.

@article{Kohanbash2013GMCSFPT,
  title={GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α.},
  author={Gary Kohanbash and Kayla McKaveney and Masashi Sakaki and Ryo Ueda and Arlan H. Mintz and Nduka M. Amankulor and Mitsugu Fujita and John R. Ohlfest and Hideho Okada},
  journal={Cancer research},
  year={2013},
  volume={73 21},
  pages={6413-23}
}
Malignant gliomas are lethal cancers in the brain and heavily infiltrated by myeloid cells. Interleukin-4 receptor-α (IL-4Rα) mediates the immunosuppressive functions of myeloid cells, and polymorphisms in the IL-4Rα gene are associated with altered glioma risk and prognosis. In this study, we sought to evaluate a hypothesized causal role for IL-4Rα and myeloid suppressor cells in glioma development. In both mouse de novo gliomas and human glioblastoma cases, IL-4Rα was upregulated on glioma… CONTINUE READING