GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells.

Abstract

Myeloid cells from non-obese diabetic (NOD) mouse and human type 1 diabetic (T1D) patients overexpress granulocyte-macrophage colony stimulation factor (GM-CSF). This overproduction prolongs the activation of signal transduction and activator of transcription 5 (STAT5) proteins, involved in GM-CSF-induced control of myeloid cell gene expression. We found… (More)
DOI: 10.1016/j.jaut.2008.08.010

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Cite this paper

@article{Seydel2008GMCSFIS, title={GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells.}, author={Federica Seydel and Erin Garrigan and B. Stutevoss and Nicole S. Belkin and B Makadia and Janice Carter and J D Shi and Abdoreza Davoodi-Semiromi and Marcia Mcduffie and Sally A. Litherland}, journal={Journal of autoimmunity}, year={2008}, volume={31 4}, pages={377-84} }