GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.

@article{Hirata2010GMCSFfacilitatedDC,
  title={GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen.},
  author={Yoshihiro Hirata and Laia Egea and Sara M. Dann and Lars Eckmann and Martin F. Kagnoff},
  journal={Cell host & microbe},
  year={2010},
  volume={7 2},
  pages={151-63}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes dendritic cell (DC) differentiation and survival in vitro. However, its role in host defense at the intestinal mucosa is unknown. We report that infection with the mouse enteric pathogen, Citrobacter rodentium, increased colonic GM-CSF production and CD11c(+) DC recruitment. After infection, GM-CSF(-/-) mice had fewer mucosal CD11c(+) DCs, greater bacterial burden, increased mucosal inflammation and systemic spread of infection… CONTINUE READING
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