GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor.

@article{Schuler1988GMCSFAO,
  title={GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor.},
  author={Gerd Schuler and Michael D. Cole},
  journal={Cell},
  year={1988},
  volume={55 6},
  pages={1115-22}
}
Regulation of mRNA turnover has emerged as an important control point in lymphokine and oncogene expression. We have studied a monocytic tumor in which activation of GM-CSF expression results from the constitutive stabilization of the normally short-lived GM-CSF mRNA. Linkage of the germ-line 3' untranslated region of the GM-CSF gene to a neo reporter gene demonstrated that mRNA stabilization is mediated by a tumor-specific trans-acting factor(s), rather than by an alteration of the GM-CSF gene… CONTINUE READING

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