GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

@article{Caux1992GMCSFAT,
  title={GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells},
  author={Christophe Caux and Colette Dezutter-Dambuyant and Daniel R Schmitt and Jacques Banchereau},
  journal={Nature},
  year={1992},
  volume={360},
  pages={258-261}
}
DENDRITIC cells comprise a system of highly efficient antigen-presenting cells which initiate immune responses such as the sensitization of T cells restricted by major histocompatibility complex molecules, the rejection of organ transplants and the formation of T-cell-dependent antibodies. Dendritic cells are found in many non-lymphoid tissues, such as skin (Langerhans cells) and mucosa, and they migrate after antigen capture through the afferent lymph or the bloodstream to lymphoid organs… CONTINUE READING